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The clinical picture is dominated by a predisposition to vascular occlusive events and hemorrhages. Some patients with ET are asymptomatic, while others may experience。

ET usually develops very slowly. It can affect people of any age. But it usually affects middle aged and older people. The average age at diagnosis is about 65 years although it can affect children and young adults.

In patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of reactive causes is particularly important ().In studies of。

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